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Article

Specific features of a scaffolding antibody light chain.

Protein science : a publication of the Protein Society - 1 May 2024

Trommer Johanna, Lesniowski Florian, Buchner Johannes, Svilenov Hristo L

Abstract excerpt

The antigen-binding sites in conventional antibodies are formed by hypervariable complementarity-determining regions (CDRs) from both heavy chains (HCs) and light chains (LCs). A deviation from this paradigm is found in a subset of bovine antibodies that bind antigens via an ultra-long CDR. The HCs bearing ultra-long CDRs pair with a restricted set of highly conserved LCs that convey stability to the antibody....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38607241
DOI: 10.1002/pro.4990
PMCID: PMC11010950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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