Article
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins.
PLoS biology - 1 Nov 2006
Rutkowski D Thomas, Arnold Stacey M, Miller Corey N, Wu Jun, Li Jack, Gunnison Kathryn M, Mori Kazutoshi, Sadighi Akha Amir A, Raden David, Kaufman Randal J
Abstract excerpt
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates a signaling cascade known as the unfolded protein response (UPR). Although activation of the UPR is well described, there is little sense of how the response, which initiates both apoptotic and adaptive pathways, ca...
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