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Article

Resistance to linezolid in Staphylococcus spp. clinical isolates associated with ribosomal binding site modifications: novel mutation in domain V of 23S rRNA.

The new microbiologica - 1 Oct 2016

Musumeci Rosario, Calaresu Enrico, Gerosa Jolanda, Oggioni Davide, Bramati Simone, Morelli Patrizia, Mura Ida, Piana Andrea, Are Bianca Maria, Cocuzza Clementina Elvezia

Abstract excerpt

Linezolid is the main representative of the oxazolidinones, introduced in 2000 in clinical practice to treat severe Gram-positive infections. This compound inhibits protein synthesis by binding to the peptidyl transferase centre of the 50S bacterial ribosomal subunit. The aim of this study was to characterize 12 clinical strains of linezolid-resistant Staphylococcus spp. isolated in Northern Italy. All isolates...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27727405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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