Article
Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 May 2009
Graciolli Fabiana G, Neves Katia R, dos Reis Luciene M, Graciolli Rafael G, Noronha Irene L, Moysés Rosa M A, Jorgetti Vanda
Abstract excerpt
BACKGROUND: Vascular calcification (VC) is commonly seen in patients with chronic kidney disease (CKD). Elevated levels of phosphate and parathormone (PTH) are considered nontraditional risk factors for VC. It has been shown that, in vitro, phosphate transforms vascular smooth muscle cells (VSMCs) into calcifying cells, evidenced by upregulated expression of runt-related transcription factor 2 (Runx2), whereas...
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