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Article

Genetic background of Prop1(df) mutants provides remarkable protection against hypothyroidism-induced hearing impairment.

Journal of the Association for Research in Otolaryngology : JARO - 1 Apr 2012

Fang Qing, Giordimaina Alicia M, Dolan David F, Camper Sally A, Mustapha Mirna

Abstract excerpt

Hypothyroidism is a cause of genetic and environmentally induced deafness. The sensitivity of cochlear development and function to thyroid hormone (TH) mandates understanding TH action in this sensory organ. Prop1(df) and Pou1f1(dw) mutant mice carry mutations in different pituitary transcription factors, each resulting in pituitary thyrotropin deficiency. Despite the same lack of detectable serum TH, these...

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Share to Hair Cells, Auditory, Outer
Share to Hearing Loss

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to KCNQ Potassium Channels

Share to Mice, Inbred DBA

Share to Potassium Channels, Inwardly Rectifying

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Share to Transcription Factor Pit-1

Source

Open in PubMed Open full text

Identifiers

PMID: 22143287
DOI: 10.1007/s10162-011-0302-3
PMCID: PMC3298611

Genes

KCNJ10
KCNQ4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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