Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Sept 2017

Xie Wei Rose, Jen Hsin-I, Seymour Michelle L, Yeh Szu-Ying, Pereira Fred A, Groves Andrew K, Klisch Tiemo J, Zoghbi Huda Y

Abstract excerpt

Atonal homolog 1 (Atoh1) is a basic helix-loop-helix (bHLH) transcription factor that is essential for the genesis, survival, and maturation of a variety of neuronal and non-neuronal cell populations, including those involved in proprioception, interoception, balance, respiration, and hearing. Such diverse functions require fine regulation at the transcriptional and protein levels. Here, we show that serine 193...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Basic Helix-Loop-Helix Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knock-In Techniques

Share to Hair Cells, Auditory

Share to Hearing Loss

Share to Movement Disorders

Share to Mutation, Missense

Share to Serine

Source

Open in PubMed Open full text

Identifiers

PMID: 28729444
DOI: 10.1523/JNEUROSCI.0295-17.2017
PMCID: PMC6596675

Genes

ATOH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Atoh1-S193A Phospho-Mutant Allele Causes Hearing Deficits and Motor Impairment.PMID 28729444Read ↗

A new mutation of the Atoh1 gene in mice with normal life span allows analysis of inner ear and cerebellar phenotype in aging.Semantic proximity Read ↗

Dominant and recessive ATOH1 variants cause distinct neurodevelopmental disorders with hearing loss.Semantic proximity Read ↗

Generation and characterization of Atoh1-Cre knock-in mouse line.Semantic proximity Read ↗

Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor.Semantic proximity Read ↗

Wfs1E864K knock-in mice illuminate the fundamental role of Wfs1 in endocochlear potential productionSemantic proximity Read ↗

A Novel PTPRQ c.3697del Variant Causes Autosomal Dominant Progressive Hearing Loss in Both Humans and Mice.Semantic proximity Read ↗

The frequency dependence of prestin-mediated fast electromotility for mammalian cochlear amplificationSemantic proximity Read ↗

Dysregulation of Serpinb6a-Gch1 axis contributes to DFNB91 deafness that is amendable to gene therapies.Semantic proximity Read ↗

Disruption of the autism-related gene Pak1 causes stereocilia disorganization, hair cell loss, and deafness in miceSemantic proximity Read ↗

An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss.Semantic proximity Read ↗

A role for mutations in AK9 and other genes affecting ependymal cells in idiopathic normal pressure hydrocephalus.Semantic proximity Read ↗

Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.