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Article

A modifier gene alleviates hypothyroidism-induced hearing impairment in Pou1f1dw dwarf mice.

Genetics - 1 Oct 2011

Fang Qing, Longo-Guess Chantal, Gagnon Leona H, Mortensen Amanda H, Dolan David F, Camper Sally A, Johnson Kenneth R

Abstract excerpt

Thyroid hormone has pleiotropic effects on cochlear development, and genomic variation influences the severity of associated hearing deficits. DW/J-Pou1f1dw/dw mutant mice lack pituitary thyrotropin, which causes severe thyroid hormone deficiency and profound hearing impairment. To assess the genetic complexity of protective effects on hypothyroidism-induced hearing impairment, an F1 intercross was generated...

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Share to Chromosomes, Mammalian
Share to Genes, Modifier

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Inbred AKR

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Source

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Identifiers

PMID: 21840860
DOI: 10.1534/genetics.111.130633
PMCID: PMC3189808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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