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Article

Loop nucleotides control primary and mature miRNA function in target recognition and repression.

RNA biology - 1 Jan 2000

Yue Si-Biao, Trujillo Robin Deis, Tang Yujie, O'Gorman William E, Chen Chang-Zheng

Abstract excerpt

MicroRNA (miRNA) genes produce three major RNA products; primary (pri-), precursor (pre-), and mature miRNAs. Each product includes sequences complementary to cognate targets, thus they all can in principle interact with the targets. In a recent study we showed that pri-miRNAs play a direct role in target recognition and repression in the absence of functional mature miRNAs. Here we examined the functional...

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Identifiers

PMID: 22142974
DOI: 10.4161/rna.8.6.17626
PMCID: PMC3256424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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