Article
Mre11 modulates the fidelity of fusion between short telomeres in human cells.
Nucleic acids research - 1 Mar 2012
Tankimanova Maira, Capper Rebecca, Letsolo Boitelo T, Rowson Jan, Jones Rhiannon E, Britt-Compton Bethan, Taylor A Malcolm R, Baird Duncan M
Abstract excerpt
The loss of telomere function can result in the fusion of telomeres with other telomeric loci, or non-telomeric double-stranded DNA breaks. Sequence analysis of fusion events between short dysfunctional telomeres in human cells has revealed that fusion is characterized by a distinct molecular signature consisting of extensive deletions and micro-homology at the fusion points. This signature is consistent with...
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