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Article

Multiple roles for MRE11 at uncapped telomeres.

Nature - 13 Aug 2009

Deng Yibin, Guo Xiaolan, Ferguson David O, Chang Sandy

Abstract excerpt

Progressive telomere attrition or uncapping of the shelterin complex elicits a DNA damage response as a result of a cell's inability to distinguish dysfunctional telomeric ends from DNA double-strand breaks. Telomere deprotection activates both ataxia telangiectasia mutated (ATM) and telangiectas...

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Topics

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Share to Ataxia Telangiectasia Mutated Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

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Share to Tumor Suppressor p53-Binding Protein 1

Source

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Identifiers

PMID: 19633651
DOI: 10.1038/nature08196
PMCID: PMC2760383

Genes

MRE11
ATM
LIG4
ATR
NBN
RAD50
TPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19633651-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Multiple roles for MRE11 at uncapped telomeres.PMID 19633651Read ↗

The MRN complex in double-strand break repair and telomere maintenance.Semantic proximity Read ↗

The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage.Semantic proximity Read ↗

The role of the Mre11-Rad50-Xrs2 complex in telomerase- mediated lengthening of Saccharomyces cerevisiae telomeres.Semantic proximity Read ↗

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together.Semantic proximity Read ↗

Reduced levels of MRE11 cause disease phenotypes distinct from ataxia telangiectasia-like disorder.Semantic proximity Read ↗

MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.Semantic proximity Read ↗

Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.Semantic proximity Read ↗

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.Semantic proximity Read ↗

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Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.Semantic proximity Read ↗

Differential expression of a disease-associated <i>MRE11</i> variant reveals distinct phenotypic outcomesSemantic proximity Read ↗

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