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Article

Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene

1 Dec 2011

Abstract excerpt

Recent studies have established that two core members of the SWI/SNF chromatin remodeling complex, BRG1 and SNF5/INI1, possess tumor-suppressor activity in human and mouse cancers. While the third core member, BAF155, has been implicated by several studies as having a potential role in tumor development, direct evidence for its tumor suppressor activity has remained lacking. Therefore, we screened for BAF155...

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PMID: 22139574
DOI: 10.4161/epi.6.12.18492

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Related research

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Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor genePMID 22139574Read ↗

Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignanciesSemantic proximity Read ↗

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Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumorsSemantic proximity Read ↗

Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation.Semantic proximity Read ↗

The SMARCA4 R1157W mutation accelerates colorectal cancer progression by facilitating SMARCA4 recruitment to H4R3me2a and chromatin remodelingSemantic proximity Read ↗

BRG1, a component of the SWI-SNF complex, is mutated in multiple human tumor cell lines.Semantic proximity Read ↗

Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF.Semantic proximity Read ↗

Oncogenesis Caused by Loss of the SNF5 Tumor Suppressor Is Dependent on Activity of BRG1, the ATPase of the SWI/SNF Chromatin Remodeling ComplexSemantic proximity Read ↗

The SMARCA4R1157W mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancerSemantic proximity Read ↗

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