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Article

A bone-seeking clone exhibits different biological properties from the ACHN parental human renal cell carcinoma in vivo and in vitro.

Oncology reports - 1 Apr 2012

Wang Jiang, Chen Anmin, Yang Caihong, Zeng Heng, Qi Jun, Guo Feng-Jin

Abstract excerpt

Metastatic bone disease caused by renal cell carcinoma (RCC) occurs frequently. Very little is currently known about the mechanism of preferential metastasis of RCC to bone. We hypothesize that RCCs that develop bone metastases have the capacity to facilitate their colonization in bone. To examine this hypothesis, we established bone-seeking (ACHN-BO) clones of the human RCC cell line ACHN by repeated four...

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Identifiers

PMID: 22139406
DOI: 10.3892/or.2011.1572
PMCID: PMC3583590

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Source receipt: pubmed, retrieved 7 Sept 2026.

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