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Establishment and characterization of NCC-GCTB14-C1 and NCC-GCTB15-C1: two novel patient-derived cell lines of giant cell tumor of bone.

Human cell - 27 Nov 2024

Iwata Shuhei, Ono Takuya, Noguchi Rei, Osaki Julia, Adachi Yuki, Shiota Yomogi, Iwata Shintaro, Nishino Shogo, Yoshida Akihiko, Ohtori Seiji, Kawai Akira, Kondo Tadashi

Abstract excerpt

Giant cell tumor of bone (GCTB) is a rare bone tumor that is genetically characterized by a unique mutation in the H3-3A gene. Curative surgical resection is the standard treatment. Unfortunately, a considerable proportion of patients with GCTB have local recurrence and pulmonary metastasis after surgical treatment, and current chemotherapy treatments have shown non-effective. Considering the heterogeneity of the...

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PMID: 39604602
DOI: 10.1007/s13577-024-01150-2

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