Article
A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis.
Nature genetics - 4 Dec 2011
Lin Zhiming, Bei Jin-Xin, Shen Meixin, Li Qiuxia, Liao Zetao, Zhang Yanli, Lv Qing, Wei Qiujing, Low Hui-Qi, Guo Yun-Miao, Cao Shuangyan, Yang Mingcan, Hu Zaiying, Xu Manlong, Wang Xinwei, Wei Yanlin, Li Li, Li Chao, Li Tianwang, Huang Jianlin, Pan Yunfeng, Jin Ou, Wu Yuqiong, Wu Jing, Guo Zishi, He Peigen, Hu Shaoxian, Wu Husheng, Song Hui, Zhan Feng, Liu Shengyun, Gao Guanmin, Liu Zhangsuo, Li Yinong, Xiao Changhong, Li Juan, Ye Zhizhong, He Weizhen, Liu Dongzhou, Shen Lingxun, Huang Anbin, Wu Henglian, Tao Yi, Pan Xieping, Yu Buyun, Tai E Shyong, Zeng Yi-Xin, Ren Ee Chee, Shen Yan, Liu Jianjun, Gu Jieruo
Abstract excerpt
To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new...
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