Article
Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci.
Nature genetics - 1 Jul 2013
Cortes Adrian, Hadler Johanna, Pointon Jenny P, Robinson Philip C, Karaderi Tugce, Leo Paul, Cremin Katie, Pryce Karena, Harris Jessica, Lee Seunghun, Joo Kyung Bin, Shim Seung-Cheol, Weisman Michael, Ward Michael, Zhou Xiaodong, Garchon Henri-Jean, Chiocchia Gilles, Nossent Johannes, Lie Benedicte A, Førre Øystein, Tuomilehto Jaakko, Laiho Kari, Jiang Lei, Liu Yu, Wu Xin, Bradbury Linda A, Elewaut Dirk, Burgos-Vargas Ruben, Stebbings Simon, Appleton Louise, Farrah Claire, Lau Jonathan, Kenna Tony J, Haroon Nigil, Ferreira Manuel A, Yang Jian, Mulero Juan, Fernandez-Sueiro Jose Luis, Gonzalez-Gay Miguel A, Lopez-Larrea Carlos, Deloukas Panos, Donnelly Peter, Bowness Paul, Gafney Karl, Gaston Hill, Gladman Dafna D, Rahman Proton, Maksymowych Walter P, Xu Huji, Crusius J Bart A, van der Horst-Bruinsma Irene E, Chou Chung-Tei, Valle-Oñate Raphael, Romero-Sánchez Consuelo, Hansen Inger Myrnes, Pimentel-Santos Fernando M, Inman Robert D, Videm Vibeke, Martin Javier, Breban Maxime, Reveille John D, Evans David M, Kim Tae-Hwan, Wordsworth Bryan Paul, Brown Matthew A
Abstract excerpt
Ankylosing spondylitis is a common, highly heritable inflammatory arthritis affecting primarily the spine and pelvis. In addition to HLA-B*27 alleles, 12 loci have previously been identified that are associated with ankylosing spondylitis in populations of European ancestry, and 2 associated loci have been identified in Asians. In this study, we used the Illumina Immunochip microarray to perform a case-control...
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