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Article

Retinoid-regulated FGF8f secretion by osteoblasts bypasses retinoid stimuli to mediate granulocytic differentiation of myeloid leukemia cells.

Molecular cancer therapeutics - 1 Feb 2012

Chaudhry Parvesh, Yang Xiaochun, Wagner Michael, Jong Ambrose, Wu Lingtao

Abstract excerpt

Signaling from the human hematopoietic stem cell (HSC) niche formed by osteoblastic cells regulates hematopoiesis. We previously found that retinoic acid receptor alpha (RARα), a transcription factor activated by retinoic acid (RA), mediates both granulocytic and osteoblastic differentiation. This effect depends on decreased phosphorylation of serine 77 of RARα (RARαS77) by the cyclin-dependent kinase-activating...

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Identifiers

PMID: 22135230
DOI: 10.1158/1535-7163.MCT-11-0584
PMCID: PMC3277667

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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