Article
Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling.
Histology and histopathology - 1 Jan 2002
Marie P J, Debiais F, Haÿ E
Abstract excerpt
The formation of cranial bone requires the differentiation of osteoblasts from undifferentiated mesenchymal cells. The balance between osteoblast recruitment, proliferation, differentiation and apoptosis in sutures between cranial bones is essential for calvarial bone formation. The mechanisms that control human osteoblasts during normal calvarial bone formation and premature suture ossification...
Topics
- Apoptosis
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Proteins
- Cell Differentiation
- Cell Division
- Fibroblast Growth Factor 2
- Gene Expression Regulation
- Humans
- Models, Biological
- Osteoblasts
- Phenotype
- Receptor Protein-Tyrosine Kinases
- Receptor, Fibroblast Growth Factor, Type 2
- Receptors, Fibroblast Growth Factor
- Signal Transduction
- Skull
- Time Factors
- Transforming Growth Factor beta