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Article

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR.

The Journal of clinical investigation - 1 Jan 2012

Schoppy David W, Ragland Ryan L, Gilad Oren, Shastri Nishita, Peters Ashley A, Murga Matilde, Fernandez-Capetillo Oscar, Diehl J Alan, Brown Eric J

Abstract excerpt

Oncogenic Ras and p53 loss-of-function mutations are common in many advanced sporadic malignancies and together predict a limited responsiveness to conventional chemotherapy. Notably, studies in cultured cells have indicated that each of these genetic alterations creates a selective sensitivity to ataxia telangiectasia and Rad3-related (ATR) pathway inhibition. Here, we describe a genetic system to conditionally...

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Source

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Identifiers

PMID: 22133876
DOI: 10.1172/JCI58928
PMCID: PMC3248295

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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