Article
Wild-type H- and N-Ras promote mutant K-Ras-driven tumorigenesis by modulating the DNA damage response.
Cancer cell - 10 Feb 2014
Grabocka Elda, Pylayeva-Gupta Yuliya, Jones Mathew J K, Lubkov Veronica, Yemanaberhan Eyoel, Taylor Laura, Jeng Hao Hsuan, Bar-Sagi Dafna
Abstract excerpt
Mutations in KRAS are prevalent in human cancers and universally predictive of resistance to anticancer therapeutics. Although it is widely accepted that acquisition of an activating mutation endows RAS genes with functional autonomy, recent studies suggest that the wild-type forms of Ras may contribute to mutant Ras-driven tumorigenesis. Here, we show that downregulation of wild-type H-Ras or N-Ras in mutant...
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