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Article

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL -rearranged AML

13 Sept 2016

Abstract excerpt

Among the various subtypes of acute myeloid leukemia (AML), those with chromosomal rearrangements of the MLL oncogene (AML-MLL) have a poor prognosis. AML-MLL tumor cells are resistant to current genotoxic therapies because of an attenuated response by p53, a protein that induces cell cycle arrest and apoptosis in response to DNA damage. In addition to chemicals that damage DNA, efforts have focused on targeting...

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PMID: 27625305
DOI: 10.1126/scisignal.aad8243

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Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL -rearranged AMLPMID 27625305Read ↗

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