RAS/BRAF wild-type metastatic high-methylated colorectal cancer has gene expression patterns related to MSI-H and BRAF V600E mutant: a translational research.

doi:10.1038/s41598-026-42033-w

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Article

RAS/BRAF wild-type metastatic high-methylated colorectal cancer has gene expression patterns related to MSI-H and BRAF V600E mutant: a translational research.

Scientific reports - 8 Mar 2026

Wakayama Shonosuke, Takahashi Shin, Ouchi Kota, Sakamoto Yasuhiro, Denda Tadamichi, Takashima Atsuo, Komatsu Yoshito, Nakamura Masato, Ohori Hisatsugu, Yamaguchi Tatsuro, Kobayashi Yoshimitsu, Baba Hideo, Kotake Masanori, Amagai Kenji, Kondo Hitoshi, Shimada Ken, Yamada Yasuhide, Sato Atsushi, Yuki Satoshi, Okita Akira, Komine Keigo, Watanabe Mika, Morita Satoshi, Ishioka Chikashi

Abstract excerpt

Metastatic colorectal cancer (mCRC) differs clinically based on RAS and BRAF mutations or DNA methylation. However, in mCRC, the prognostic value and biological characteristics of genome-wide DNA methylation status (GWMS) in each RAS/BRAF genotype is unknown. To clarify this, primary tumor samples from patients with informed consent in the phase III TRICOLORE study were collected, and RAS and BRAF mutations,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41796183
DOI: 10.1038/s41598-026-42033-w
PMCID: PMC13086851

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BRAF

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