Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study.

BMC medical genetics - 17 Mar 2009

Dahlman Ingrid, Nilsson Maria, Gu Harvest F, Lecoeur Cecile, Efendic Suad, Ostenson Claes G, Brismar Kerstin, Gustafsson Jan-Ake, Froguel Philippe, Vaxillaire Martine, Dahlman-Wright Karin, Steffensen Knut R

Abstract excerpt

BACKGROUND: Liver X receptor alpha (LXRA) and beta (LXRB) regulate glucose and lipid homeostasis in model systems but their importance in human physiology is poorly understood. This project aimed to determine whether common genetic variations in LXRA and LXRB associate with type 2 diabetes (T2D) and quantitative measures of glucose homeostasis, and, if so, reveal the underlying mechanisms. METHODS: Eight common...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chi-Square Distribution
Share to Electrophoretic Mobility Shift Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to France

Share to Genes, Reporter

Share to Liver X Receptors

Share to Orphan Nuclear Receptors

Share to Receptors, Cytoplasmic and Nuclear

Share to Sweden

Source

Open in PubMed Open full text

Identifiers

PMID: 19292929
DOI: 10.1186/1471-2350-10-27
PMCID: PMC2664799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study.PMID 19292929Read ↗

Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe).Semantic proximity Read ↗

Associations between liver X receptor polymorphisms and blood lipids: A systematic review and meta-analysis.Semantic proximity Read ↗

Genetic variation within the NR1H2 gene encoding liver X receptor β associates with insulin secretion in subjects at increased risk for type 2 diabetes.Semantic proximity Read ↗

Adrenergic receptor beta-3 rs4994 (T>C) and liver X receptor alpha rs12221497 (G>A) polymorphism in Pakistanis with metabolic syndrome.Semantic proximity Read ↗

Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity.Semantic proximity Read ↗

Farnesoid x receptor in human metabolism and disease: the interplay between gene polymorphisms, clinical phenotypes and disease susceptibility.Semantic proximity Read ↗

Single gene contributions: genetic variants of peroxisome proliferator-activated receptor (isoforms alpha, beta/delta and gamma) and mechanisms of dyslipidemias.Semantic proximity Read ↗

Association between liver X receptor alpha gene polymorphisms and risk of metabolic syndrome in French populations.Semantic proximity Read ↗

Nuclear receptor variants in liver disease.Semantic proximity Read ↗

Genetic variation in NR1H4 encoding the bile acid receptor FXR determines fasting glucose and free fatty acid levels in humans.Semantic proximity Read ↗

Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population.Semantic proximity Read ↗

Liver X receptor α gene polymorphisms and variable cardiovascular outcomes in patients treated with antihypertensive therapy: results from the INVEST-GENES study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.