Article
IL23R gene polymorphism with juvenile idiopathic arthritis and its association with serum IL-17A.
International journal of rheumatic diseases - 1 Nov 2016
Emami Samira, Ziaee Vahid, Rezaei Arezou, Sadr Maryam, Maddah Marzieh, Amirzargar Ali Akbar, Rezaei Nima
Abstract excerpt
AIM: Interleukin 23 (IL-23) and its receptor (IL-23R) seem to play a major role in differentiation of CD4+ T cells into Th17 cells, induction of IL-17 production, and activation of inflammatory pathways. Recent studies have suggested the association of IL-23R polymorphisms with bone and articular inflammation in diseases such as ankylosing spondylitis and rheumatoid arthritis. The aim of this study was to...
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