Article
A variant in LDLR is associated with abdominal aortic aneurysm.
Circulation. Cardiovascular genetics - 1 Oct 2013
Bradley Declan T, Hughes Anne E, Badger Stephen A, Jones Gregory T, Harrison Seamus C, Wright Benjamin J, Bumpstead Suzannah, Baas Annette F, Grétarsdóttir Sólveig, Burnand Kevin, Child Anne H, Clough Rachel E, Cockerill Gillian, Hafez Hany, Scott D Julian A, Ariëns Robert A S, Johnson Anne, Sohrabi Soroush, Smith Alberto, Thompson Matthew M, van Bockxmeer Frank M, Waltham Matthew, Matthíasson Stefán E, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Blankensteijn Jan D, Teijink Joep A W, Wijmenga Cisca, de Graaf Jacqueline, Kiemeney Lambertus A, Wild John B, Edkins Sarah, Gwilliam Rhian, Hunt Sarah E, Potter Simon, Lindholt Jes S, Golledge Jonathan, Norman Paul E, van Rij Andre, Powell Janet T, Eriksson Per, Stefánsson Kári, Thompson John R, Humphries Steve E, Sayers Robert D, Deloukas Panos, Samani Nilesh J, Bown Matthew J
Abstract excerpt
BACKGROUND: Abdominal aortic aneurysm (AAA) is a common cardiovascular disease among older people and demonstrates significant heritability. In contrast to similar complex diseases, relatively few genetic associations with AAA have been confirmed. We reanalyzed our genome-wide study and carried through to replication suggestive discovery associations at a lower level of significance. METHODS AND RESULTS: A...
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