Article
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.
American journal of human genetics - 11 Nov 2011
Bown Matthew J, Jones Gregory T, Harrison Seamus C, Wright Benjamin J, Bumpstead Suzannah, Baas Annette F, Gretarsdottir Solveig, Badger Stephen A, Bradley Declan T, Burnand Kevin, Child Anne H, Clough Rachel E, Cockerill Gillian, Hafez Hany, Scott D Julian A, Futers Simon, Johnson Anne, Sohrabi Soroush, Smith Alberto, Thompson Matthew M, van Bockxmeer Frank M, Waltham Matthew, Matthiasson Stefan E, Thorleifsson Gudmar, Thorsteinsdottir Unnur, Blankensteijn Jan D, Teijink Joep A W, Wijmenga Cisca, de Graaf Jacqueline, Kiemeney Lambertus A, Assimes Themistocles L, McPherson Ruth, Folkersen Lasse, Franco-Cereceda Anders, Palmen Jutta, Smith Andrew J, Sylvius Nicolas, Wild John B, Refstrup Mette, Edkins Sarah, Gwilliam Rhian, Hunt Sarah E, Potter Simon, Lindholt Jes S, Frikke-Schmidt Ruth, Tybjærg-Hansen Anne, Hughes Anne E, Golledge Jonathan, Norman Paul E, van Rij Andre, Powell Janet T, Eriksson Per, Stefansson Kari, Thompson John R, Humphries Steve E, Sayers Robert D, Deloukas Panos, Samani Nilesh J
Abstract excerpt
Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1 × 10(-5)) in 2871 additional cases and 32,687 controls and performed further follow-up in 1491 AAA and 11,060 controls. In the discovery...
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