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Article

TNF polymorphisms in psoriasis: association of psoriatic arthritis with the promoter polymorphism TNF*-857 independent of the PSORS1 risk allele.

Arthritis and rheumatism - 1 Jun 2007

Reich Kristian, Hüffmeier Ulrike, König Inke R, Lascorz Jesús, Lohmann Jörg, Wendler Jörg, Traupe Heiko, Mössner Rotraut, Reis André, Burkhardt Harald

Abstract excerpt

OBJECTIVE: Single-nucleotide polymorphisms (SNPs) of the tumor necrosis factor gene TNF at positions -238 and -308 have been associated with psoriasis vulgaris and psoriatic arthritis (PsA). The strong linkage disequilibrium (LD) at chromosome region 6p21, a region known to harbor risk factors for psoriasis susceptibility (PSORS1) other than just SNPs of the TNF gene, renders the interpretation of these findings...

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Identifiers

PMID: 17530646
DOI: 10.1002/art.22590

Genes

TNF
CCHCR1
LTA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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TNF polymorphisms in psoriasis: association of psoriatic arthritis with the promoter polymorphism TNF*-857 independent of the PSORS1 risk allele.PMID 17530646Read ↗

Tumor necrosis factor promoter polymorphism TNF*-857 is a risk allele for psoriatic arthritis independent of the PSORS1 locus.Semantic proximity Read ↗

Single nucleotide polymorphisms in the tumor necrosis factor-alpha gene promoter region alter the risk of psoriasis vulgaris and psoriatic arthritis: a meta-analysis.Semantic proximity Read ↗

Complex role of TNF variants in psoriatic arthritis and treatment response to anti-TNF therapy: evidence and concepts.Semantic proximity Read ↗

Functional study of TNF-α as a promoter of polymorphisms in psoriasis.Semantic proximity Read ↗

Differential association of polymorphisms in the TNFalpha region with psoriatic arthritis but not psoriasis.Semantic proximity Read ↗

TNF-α gene polymorphisms: association with disease susceptibility and response to anti-TNF-α treatment in psoriatic arthritis.Semantic proximity Read ↗

308G/A and 238G/A polymorphisms in the TNF-α gene may not contribute to the risk of arthritis among Turkish psoriatic patientsSemantic proximity Read ↗

TNF-alpha gene promoter -238G>A and -308G>A polymorphisms alter risk of psoriasis vulgaris: a meta-analysis.Semantic proximity Read ↗

Association of the tumour necrosis factor-α polymorphisms rs361525 and rs1800629 with susceptibility to psoriasis: a meta-analysis.Semantic proximity Read ↗

A - 308 promoter polymorphism of tumor necrosis factor alpha gene does not associate with the susceptibility to psoriasis vulgaris. No difference either between psoriasis type I and type II patients.Semantic proximity Read ↗

HLA-C and TNF gene polymorphisms are associated with psoriasis in Brazilian patients.Semantic proximity Read ↗

Human leukocyte antigen (HLA) and single nucleotide polymorphisms (SNPs) tumor necrosis factor (TNF)-alpha -238 and -308 as genetic markers of susceptibility to psoriasis and severity of the disease in a long-term follow-up Brazilian study.Semantic proximity Read ↗

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