Article
On the simultaneous association analysis of large genomic regions: a massive multi-locus association test.
Bioinformatics (Oxford, England) - 15 Jan 2014
Qiao Dandi, Cho Michael H, Fier Heide, Bakke Per S, Gulsvik Amund, Silverman Edwin K, Lange Christoph
Abstract excerpt
MOTIVATION: For samples of unrelated individuals, we propose a general analysis framework in which hundred thousands of genetic loci can be tested simultaneously for association with complex phenotypes. The approach is built on spatial-clustering methodology, assuming that genetic loci that are associated with the target phenotype cluster in certain genomic regions. In contrast to standard methodology for...
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