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Article

Genetic analysis of Leishmania mexicana infection in mice: single gene (Scl-2) controlled predisposition to cutaneous lesion development.

Journal of immunogenetics - 1 Jan 2000

Roberts M, Alexander J, Blackwell J M

Abstract excerpt

Subcutaneous inoculation of Leishmania mexicana amastigotes into the shaven rumps of DBA/2 mice results in a unique 'no lesion growth' phenotype not observed in other mouse strains. Statistical analysis (Kolmogorov-Smirnov and log likelihood tests) of lesion diameters in F1, F2 and backcross progeny from (C57BL/6 x DBA/2) matings indicate that segregation between lesion growth and no lesion growth phenotypes...

Topics

Animals
Chromosome Mapping
Crosses, Genetic
Female
Leishmaniasis
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Models, Genetic
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2212703
DOI: 10.1111/j.1744-313x.1990.tb00862.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2212703-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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