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Article

Canonical and non-canonical JAK/STAT transcriptional targets may be involved in distinct and overlapping cellular processes.

BMC genomics - 11 Sept 2017

Tsurumi Amy, Zhao Connie, Li Willis X

Abstract excerpt

BACKGROUND: The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway has been well-characterized as a crucial signal transduction cascade that regulates vital biological responses including development, immunity and oncogenesis. Additionally to its canonical pathway that uses the phosphorylated form of the STAT transcription factor, recently the non-canonical pathway involving...

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Identifiers

PMID: 28893190
DOI: 10.1186/s12864-017-4058-y
PMCID: PMC5594485

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