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Article

Sobp modulates the transcriptional activation of Six1 target genes and is required during craniofacial development

20 Aug 2021

Abstract excerpt

Branchio-oto-renal syndrome (BOR) is a disorder characterized by hearing loss, and craniofacial and/or renal defects. Variants in the transcription factor Six1 and its co-factor Eya1, both of which are required for otic development, are linked to BOR. We previously identified Sobp as a potential Six1 co-factor, and SOBP variants in mouse and humans cause otic phenotypes; therefore, we asked whether Sobp interacts...

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PMID: 34414417
DOI: 10.1242/dev.199684

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