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Article

Structural insights into a zinc-dependent pathway leading to Leu55Pro transthyretin amyloid fibrils.

Acta crystallographica. Section D, Biological crystallography - 1 Dec 2011

Castro-Rodrigues Artur F, Gales Luís, Saraiva Maria J, Damas Ana M

Abstract excerpt

Human transthyretin (TTR) is a homotetrameric protein that is responsible for the formation of amyloid in patients with familiar amyloidotic polyneuropathy (FAP), familiar amyloidotic cardiomyopathy (FAC) and senile systemic amyloidosis (SSA). Amyloid fibrils are characterized by a cross-β structure. However, details of how TTR monomers are organized to form such an assembly remain unknown. The effect of Zn(2+)...

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Source

Identifiers

PMID: 22120741
DOI: 10.1107/S090744491104491X

Genes

TTR
FAP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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