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Article

A comparative analysis of 23 structures of the amyloidogenic protein transthyretin.

Journal of molecular biology - 22 Sept 2000

Hörnberg A, Eneqvist T, Olofsson A, Lundgren E, Sauer-Eriksson A E

Abstract excerpt

Self-assembly of the human plasma protein transthyretin (TTR) into unbranched insoluble amyloid fibrils occurs as a result of point mutations that destabilize the molecule, leading to conformational changes. The tertiary structure of native soluble TTR and many of its disease-causing mutants have been determined. Several independent studies by X-ray crystallography have suggested structural differences between...

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Source

Identifiers

PMID: 10986125
DOI: 10.1006/jmbi.2000.4078

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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