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Article

Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity.

Biochemistry - 16 Nov 1993

McCutchen S L, Colon W, Kelly J W

Abstract excerpt

A recently reported variant of human transthyretin (TTR), Leu-55-Pro, implicated as the causative agent in early-onset familial amyloid polyneuropathy was expressed and characterized, and its denaturation pathway and amyloidogenicity were compared to those of wild-type transthyretin. The overlap-extension polymerase chain reaction (PCR) methodology was used to introduce the Leu-55-Pro mutation into the...

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Source

Identifiers

PMID: 8218290
DOI: 10.1021/bi00096a024

Genes

TTR
SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity.PMID 8218290Read ↗

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