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Article

Transthyretin mutagenesis: impact on amyloidogenesis and disease.

Critical reviews in clinical laboratory sciences - 1 Nov 2024

Almeida Zaida L, Vaz Daniela C, Brito Rui M M

Abstract excerpt

Transthyretin (TTR), a homotetrameric protein found in plasma, cerebrospinal fluid, and the eye, plays a pivotal role in the onset of several amyloid diseases with high morbidity and mortality. Protein aggregation and fibril formation by wild-type TTR and its natural more amyloidogenic variants are hallmarks of ATTRwt and ATTRv amyloidosis, respectively. The formation of soluble amyloid aggregates and the...

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Identifiers

PMID: 38850014
DOI: 10.1080/10408363.2024.2350379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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