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Article

The beta-slip: a novel concept in transthyretin amyloidosis.

Molecular cell - 1 Nov 2000

Eneqvist T, Andersson K, Olofsson A, Lundgren E, Sauer-Eriksson A E

Abstract excerpt

Transthyretin is a tetrameric plasma protein associated with two forms of amyloid disease. The structure of the highly amyloidogenic transthyretin triple mutant TTRG53S/E54D/L55S determined at 2.3 A resolution reveals a novel conformation: the beta-slip. A three-residue shift in beta strand D places Leu-58 at the position normally occupied by Leu-55 now mutated to serine. The beta-slip is best defined in two of...

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PMID: 11106758
DOI: 10.1016/s1097-2765(00)00117-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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