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Article

Crystal structures of amyloidogenic segments of human transthyretin.

Protein science : a publication of the Protein Society - 1 Jul 2018

Saelices Lorena, Sievers Stuart A, Sawaya Michael R, Eisenberg David S

Abstract excerpt

Amyloid diseases are characterized by the deposition of proteins in the form of amyloid fibrils, in organs that eventually fail. The development of effective drug candidates follows from the understanding of the molecular processes that lead to protein aggregation. Here, we study amyloidogenic segments of transthyretin (TTR). TTR is a transporter of thyroxine and retinol in the blood and cerebrospinal fluid. When...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29626847
DOI: 10.1002/pro.3420
PMCID: PMC6032358

Genes

TTR

Provenance

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