Article
The crystal structure of amyloidogenic Leu55 --> Pro transthyretin variant reveals a possible pathway for transthyretin polymerization into amyloid fibrils.
The Journal of biological chemistry - 18 Sept 1998
Sebastião M P, Saraiva M J, Damas A M
Abstract excerpt
The x-ray crystal structure of the amyloidogenic Leu55 --> Pro transthyretin (TTR) variant, implicated as the causative agent in early-onset familial amyloidotic polyneuropathy (Jacobson, D. R., McFarlin, D. E., Kane, I., and Buxbaum, J. N. (1992) Hum. Genet. 89, 353-356), has been solved by mole...
Topics
- Amino Acid Sequence
- Amyloid Neuropathies
- Computer Simulation
- Crystallography, X-Ray
- Genetic Variation
- Humans
- Leucine
- Macromolecular Substances
- Models, Molecular
- Molecular Sequence Data
- Point Mutation
- Prealbumin
- Proline
- Protein Conformation
- Protein Structure, Secondary
- Recombinant Proteins