Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.

Science (New York, N.Y.) - 8 Oct 2010

Jones Siân, Wang Tian-Li, Shih Ie-Ming, Mao Tsui-Lien, Nakayama Kentaro, Roden Richard, Glas Ruth, Slamon Dennis, Diaz Luis A, Vogelstein Bert, Kinzler Kenneth W, Velculescu Victor E, Papadopoulos Nickolas

Abstract excerpt

Ovarian clear cell carcinoma (OCCC) is an aggressive human cancer that is generally resistant to therapy. To explore the genetic origin of OCCC, we determined the exomic sequences of eight tumors after immunoaffinity purification of cancer cells. Through comparative analyses of normal cells from the same patients, we identified four genes that were mutated in at least two tumors. PIK3CA, which encodes a subunit...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma, Clear Cell
Share to Chromatin Assembly and Disassembly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Genes, ras

Share to Genes, Tumor Suppressor

Share to Oncogenes

Share to Phosphatidylinositol 3-Kinases

Share to Protein Phosphatase 2

Source

Open in PubMed Open full text

Identifiers

PMID: 20826764
DOI: 10.1126/science.1196333
PMCID: PMC3076894

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma.PMID 20826764Read ↗

Exome Sequencing Landscape Analysis in Ovarian Clear Cell Carcinoma Shed Light on Key Chromosomal Regions and Mutation Gene Networks.Semantic proximity Read ↗

Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing.Semantic proximity Read ↗

Genomic characterization of Chinese ovarian clear cell carcinoma identifies driver genes by whole exome sequencing.Semantic proximity Read ↗

Comprehensive molecular characterization identifies therapeutic vulnerabilities in ovarian clear cell carcinoma.Semantic proximity Read ↗

Treatment Strategies for ARID1A-Deficient Ovarian Clear Cell CarcinomaSemantic proximity Read ↗

Genomic landscape of ovarian clear cell carcinoma via whole exome sequencing.Semantic proximity Read ↗

Molecular portraits of clear cell ovarian and endometrial carcinoma with comparison to clear cell renal cell carcinoma.Semantic proximity Read ↗

A comprehensive molecular analysis of 113 primary ovarian clear cell carcinomas reveals common therapeutically significant aberrationsSemantic proximity Read ↗

Precision medicine for ovarian clear cell carcinoma based on gene alterations.Semantic proximity Read ↗

Molecular profiling reveals novel therapeutic targets and clonal evolution in ovarian clear cell carcinoma.Semantic proximity Read ↗

Integrated genomic/epigenomic analysis stratifies subtypes of clear cell ovarian carcinoma, highlighting their cellular origin.Semantic proximity Read ↗

Genome-wide DNA methylation in relation to ARID1A deficiency in ovarian clear cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.