A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation.

doi:10.1186/1471-2407-14-120

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Article

A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation.

BMC cancer - 22 Feb 2014

Wiegand Kimberly C, Hennessy Bryan T, Leung Samuel, Wang Yemin, Ju Zhenlin, McGahren Mollianne, Kalloger Steve E, Finlayson Sarah, Stemke-Hale Katherine, Lu Yiling, Zhang Fan, Anglesio Michael S, Gilks Blake, Mills Gordon B, Huntsman David G, Carey Mark S

Abstract excerpt

BACKGROUND: Ovarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from endometriosis and frequently harbor mutations in the ARID1A tumor suppressor gene. We studied the influence of histological subtype on protein expression with reverse phase protein array (RPPA) and...

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PMID: 24559118
DOI: 10.1186/1471-2407-14-120
PMCID: PMC3941949

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PTEN

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