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Article

Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2012

Yamamoto Sohei, Tsuda Hitoshi, Takano Masashi, Tamai Seiichi, Matsubara Osamu

Abstract excerpt

ARID1A is a recently identified tumor suppressor gene that is mutated in ∼50% of ovarian clear-cell carcinomas. This mutation is associated with loss of ARID1A protein expression as assessed by immunohistochemistry. The present study aimed at determining the timing of the loss of ARID1A protein expression during the development of ovarian clear-cell carcinoma and assessing its relevance in correlation to PIK3CA...

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Identifiers

PMID: 22157930
DOI: 10.1038/modpathol.2011.189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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