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Article

A subset of chronic lymphocytic leukemia patients display reduced levels of PARP1 expression coupled with a defective irradiation-induced apoptosis.

Experimental hematology - 1 Mar 2012

Bacalini Maria Giulia, Tavolaro Simona, Peragine Nadia, Marinelli Marilisa, Santangelo Simona, Del Giudice Ilaria, Mauro Francesca Romana, Di Maio Valeria, Ricciardi Maria Rosaria, Caiafa Paola, Chiaretti Sabina, Foà Robin, Guarini Anna, Reale Anna

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is a heterogeneous disease characterized by defects in the DNA damage response and apoptosis. Among the factors involved in these pathways, we focused on the enzyme poly(ADP-ribose) polymerase 1 (PARP1) and on its substrate Che-1 by evaluating their basal expression and functional changes upon irradiation (IR). Microarray experiments were performed on 98 untreated CLL cases....

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Share to Gamma Rays
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Heavy Chains

Share to Immunoglobulin Variable Region

Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

Identifiers

PMID: 22120020
DOI: 10.1016/j.exphem.2011.11.005

Genes

PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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