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Article

Cisplatin Resistance Associated with PARP Hyperactivation

1 Apr 2013

Abstract excerpt

Non-small cell lung carcinoma patients are frequently treated with cisplatin (CDDP), most often yielding temporary clinical responses. Here, we show that PARP1 is highly expressed and constitutively hyperactivated in a majority of human CDDP-resistant cancer cells of distinct histologic origin. Cells manifesting elevated intracellular levels of poly(ADP-ribosyl)ated proteins (PAR(high)) responded to pharmacologic...

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PMID: 23554447
DOI: 10.1158/0008-5472.can-12-3000

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