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Article

The resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA microarrays

13 Feb 2003

Abstract excerpt

B-cell chronic lymphoid leukemia (BCLL) is a highly heterogeneous human malignancy, presumably reflecting specific molecular alterations in gene expression and protein activity that are thought to underlie the variable disease outcome. Most B-CLL cell samples undergo apoptotic death in response to DNA damage. However, a clinically distinct aggressive subset of B-CLL is completely resistant in vitro to...

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PMID: 12586635
DOI: 10.1182/blood-2002-06-1743

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