Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

c-Abl–Mediated Tyrosine Phosphorylation of PARP1 Is Crucial for Expression of Proinflammatory Genes

9 Aug 2019

Abstract excerpt

Poly(ADP-ribosyl)ation is a rapid and transient posttranslational protein modification mostly catalyzed by poly(ADP-ribose) polymerase-1 (PARP1). Fundamental roles of activated PARP1 in DNA damage repair and cellular response pathways are well established; however, the precise mechanisms by which PARP1 is activated independent of DNA damage, and thereby playing a role in expression of inflammatory genes, remain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell death mechanisms and regulation
Share to PARP inhibition in cancer therapy
Share to Toxin Mechanisms and Immunotoxins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31399520
DOI: 10.4049/jimmunol.1801616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

c-Abl–Mediated Tyrosine Phosphorylation of PARP1 Is Crucial for Expression of Proinflammatory GenesPMID 31399520Read ↗

Multifaceted Role of PARP-1 in DNA Repair and Inflammation: Pathological and Therapeutic Implications in Cancer and Non-Cancer DiseasesSemantic proximity Read ↗

The Role of PARPs in Inflammation—And Metabolic—Related Diseases: Molecular Mechanisms and BeyondSemantic proximity Read ↗

Pleiotropic Cellular Functions of PARP1 in Longevity and Aging: Genome Maintenance Meets InflammationSemantic proximity Read ↗

PARP-1: Friend or Foe of DNA Damage and Repair in Tumorigenesis?Semantic proximity Read ↗

The Multifactorial Role of PARP-1 in Tumor MicroenvironmentSemantic proximity Read ↗

PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR.Semantic proximity Read ↗

Transcriptional regulation mechanism of PARP1 and its application in disease treatmentSemantic proximity Read ↗

PARP-1: a critical regulator in radioprotection and radiotherapy-mechanisms, challenges, and therapeutic opportunitiesSemantic proximity Read ↗

Beyond DNA Repair: Additional Functions of PARP-1 in CancerSemantic proximity Read ↗

The Role of Poly(ADP‐ribose) Polymerase‐1 in Rheumatoid ArthritisSemantic proximity Read ↗

PARP1: Liaison of Chromatin Remodeling and TranscriptionSemantic proximity Read ↗

Distinct roles for PARP-1 and PARP-2 in c-Myc–driven B-cell lymphoma in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.