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Article

Biological and clinical significance of PARP1 protein expression in breast cancer.

Breast cancer research and treatment - 1 Jan 2015

Green Andrew R, Caracappa Daniela, Benhasouna Ahmed A, Alshareeda Alaa, Nolan Christopher C, Macmillan R Douglas, Madhusudan Srinivasan, Ellis Ian O, Rakha Emad A

Abstract excerpt

Poly(ADP-ribose) polymerase-1 (PARP1) is a key facilitator of DNA repair. PARP inhibitors have gained recent attention as promising therapeutic agents for the treatment of solid tumours including breast cancer (BC). However, the biological and clinical significance of PARP1 expression in BC and its role in DNA-damage response (DDR) remain to be defined. We investigated the expression of PARP1 expression, cleaved...

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Source

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Identifiers

PMID: 25528020
DOI: 10.1007/s10549-014-3230-1
PMCID: PMC4308637

Genes

PARP1
BRCA1
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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