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Article

Negative regulation by amidase PGRPs shapes the Drosophila antibacterial response and protects the fly from innocuous infection.

Immunity - 23 Nov 2011

Paredes Juan C, Welchman David P, Poidevin Mickaël, Lemaitre Bruno

Abstract excerpt

Peptidoglycan recognition proteins (PGRPs) are key regulators of insect immune responses. In addition to recognition PGRPs, which activate the Toll and Imd pathways, the Drosophila genome encodes six catalytic PGRPs with the capacity to scavenge peptidoglycan. We have performed a systematic analysis of catalytic PGRP function using deletions, separately and in combination. Our findings support the role of PGRP-LB...

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PMID: 22118526
DOI: 10.1016/j.immuni.2011.09.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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