Peptidoglycan recognition proteins: on and off switches for innate immunity

Abstract excerpt

Insects rely on innate immune mechanisms to defend themselves against microbes. The inducible anti-microbial peptides constitute an important arm of this defense. In Drosophila, the Toll and the Imd pathways are the major routes to induce the peptides, and it has become clear that to a certain extent, these pathways can discriminate between different microbes and mount an appropriate response to eliminate the...

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