Article
Psidin is required in Drosophila blood cells for both phagocytic degradation and immune activation of the fat body.
Current biology : CB - 9 Jan 2007
Brennan Catherine A, Delaney Joseph R, Schneider David S, Anderson Kathryn V
Abstract excerpt
Phagocytic blood cells are critical to innate immune defense: They internalize and destroy microbial invaders and produce signals that trigger other immune responses. Despite this central role, the in vivo contributions of phagocytosis to systemic immune activation are not well understood. Drosophila has proven a fruitful model for the investigation of evolutionarily conserved innate immune mechanisms, including...
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