Article
The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein.
Nature - 11 Apr 2002
Gottar Marie, Gobert Vanessa, Michel Tatiana, Belvin Marcia, Duyk Geoffrey, Hoffmann Jules A, Ferrandon Dominique, Royet Julien
Abstract excerpt
The antimicrobial defence of Drosophila relies largely on the challenge-induced synthesis of an array of potent antimicrobial peptides by the fat body. The defence against Gram-positive bacteria and natural fungal infections is mediated by the Toll signalling pathway, whereas defence against Gram-negative bacteria is dependent on the Immune deficiency (IMD) pathway. Loss-of-function mutations in either pathway...
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