Article
Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue.
Cancer research - 15 Nov 1995
Bell D A, Badawi A F, Lang N P, Ilett K F, Kadlubar F F, Hirvonen A
Abstract excerpt
Exposures to carcinogens present in the diet, in cigarette smoke, or in the environment have been associated with increased risk of bladder and colorectal cancer. The aromatic amines and their metabolites, a class of carcinogen implicated in these exposures, can be N- or O-acetylated by the NAT1 and NAT2 enzymes. Acetylation may result in activation to DNA-reactive metabolites or, in some cases, detoxification....
Topics
- Acetylation
- Alleles
- Arylamine N-Acetyltransferase
- Base Sequence
- Colon
- Humans
- Molecular Sequence Data
- Poly A
- Polymorphism, Genetic
- Urinary Bladder